Part I Bladder Cancer
1 Bladder Cancer Screening, Signs and Symptoms, and Workup 3
2 Cystoscopy and Enhanced Diagnostics 9
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3 Using Urinary Biomarkers in Urothelial Carcinoma of the Bladder and Upper Tracts 21
4 Pathology 33
5 Risk Stratification of Patients: Risk Tables and Assessment – NMIBC and MIBC 41
6 Perioperative Preparation and Management of Cystoscopy Patient 53
7 Transurethral Resection of Bladder Tumors (TURBT) 57
8 Single Immediate Intravesical Instillation of Chemotherapy- Rationale and Practical Considerations 71
9 Adjuvant Intravesical Therapy: Bacillus Calmette-Guerin 75
10 Adjuvant Intravesical Chemotherapy 91
11 Device-Assisted Therapies for Nonmuscle-Invasive Bladder Cancer: A Practical Approach 103
12 Intravesical Salvage Therapy After BCG/Regular Chemo 111
13 Oncological Monitoring of NonMuscle Invasive Bladder Cancer (NMIBC) 123
14 Radical Cystectomy 139
15 Surgical Technique: Urethrectomy 177
16 Management of Common Complications After Radical Cystectomy, Lymph Node Dissection, and Urinary
Diversion 185
17 Incontinent Urinary Diversion 205
18 Continent Cutaneous Urinary Diversions 219
19 Orthotopic Bladder Substitution 227
20 Neoadjuvant Chemotherapy 245
21 Adjuvant Chemotherapy in Bladder Cancer 251
22 Trimodal Therapy 257
23 Managing Urothelial Recurrences after Chemoradiation Therapy 281
24 Cytotoxic Chemotherapy for Advanced Bladder and Upper Tract Cancer 289
25 Immunotherapy for Metastatic Urothelial Carcinoma 305
26 Novel Therapies 315
27 Variant Histology: Management Pearls 323
28 Clinical Trials in Bladder and Upper Tract Cancer – Bladder Cancer Disease States 343
29 Practical Approaches to Clinical Trials in Non-muscle-Invasive Bladder Cancer 347
30 Clinical Trials in Localized Muscle-Invasive Bladder Cancer 355
31 Clinical Trials in Metastatic Urothelial Carcinoma 365
32 Clinical Trials in Upper Tract Urothelial Carcinoma 373
Part II Upper Tract Urothelial Carcinoma
33 Patient Evaluation and Diagnosis – Screening, Evaluation, and Workup 379
34 Risk Stratification of Upper Tract Urothelial Carcinoma for Kidney-Sparing Surgery 387
35 Ureteroscopic Managment of Upper Tract Urothelial Carcinoma 403
36 Adjuvant Therapy for Upper Tract Urothelial Carcinoma after Endoscopic Management 421
37 Novel Adjuvant Therapies for Upper Tract Urothelial Carcinoma After Endoscopic Management 429
38 Nephroureterectomy for Upper Tract Urothelial Carcinoma: Indications and Technique 439
39 Selection, Administration and Description of Neoadjuvant versus Adjuvant Therapy for Upper Tract
Urothelial Carcinoma 447
40 Oncologic Monitoring After Radical Nephroureterectomy 457
Index 463
This book provides a practical, comprehensive, state-of-the-art review of bladder cancer. A valuable
resource for anyone with an interest in urothelial tumors, this text brings together a multidisciplinary
team of experts who have distilled their vast years of experience and knowledge into a concise, easy to
digest format. Topics covered range from importance of a pattern recognition in diagnosis and pathologic
evaluation to ‘how I do it’ tips on patient selection for appropriate therapies such as chemotherapy,
immunotherapy, surgery and radiation. Bridging the gap between a traditional textbook and hands-on
experience, this book provides a practical guide to managing day-to-day issues and challenges and brings an
algorithmic approach to avoid common pitfalls.
Bladder Cancer: A Practical Guide provides a concise yet comprehensive summary of the current status of the
field of bladder cancer treatment, guiding patient management and stimulating investigative efforts.